The more we delve into the deep intricacies of the world, the more human creativity increases. The more we learn about life, the more we get to work with our biology for better health. “It is the glory of God to conceal a matter and the glory of kings to search it out.” It’s truly amazing to watch as our investigative powers advance. — RDM
Biologists Delay the Aging Process by “Remote Control”
by Patrick Cox
September 4, 2014
UCLA biologists have identified a gene that can slow the aging process throughout the entire body when activated remotely in key organ systems.
Working with fruit flies, the life scientists activated a gene called AMPK that is a key energy sensor in cells; it gets activated when cellular energy levels are low.
Increasing the amount of AMPK in fruit flies’ intestines increased their lifespans by about 30 percent—to roughly eight weeks from the typical six—and the flies stayed healthier longer as well.
The research, published Sept. 4 in the open-source journal Cell Reports, could have important implications for delaying aging and disease in humans, said David Walker, an associate professor of integrative biology and physiology at UCLA and senior author of the research.
“We have shown that when we activate the gene in the intestine or the nervous system, we see the aging process is slowed beyond the organ system in which the gene is activated,” Walker said.
Walker said that the findings are important because extending the healthy life of humans would presumably require protecting many of the body’s organ systems from the ravages of aging—but delivering anti-aging treatments to the brain or other key organs could prove technically difficult. The study suggests that activating AMPK in a more accessible organ such as the intestine, for example, could ultimately slow the aging process throughout the entire body, including the brain.